Hypoxia-inducible Factors in Physiology and Medicine

Cell. 2012 Feb 3;148(3):399-408. doi: 10.1016/j.cell.2012.01.021.

Abstract

Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / genetics*
  • Biological Evolution*
  • Chronic Disease
  • Embryonic Development
  • Humans
  • Hypoxia / metabolism
  • Oxygen / metabolism*

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Oxygen