Comparison of adaptive statistical iterative and filtered back projection reconstruction techniques in brain CT

Eur J Radiol. 2012 Oct;81(10):2597-601. doi: 10.1016/j.ejrad.2011.12.041. Epub 2012 Feb 1.


Purpose: To compare image quality and visualization of normal structures and lesions in brain computed tomography (CT) with adaptive statistical iterative reconstruction (ASIR) and filtered back projection (FBP) reconstruction techniques in different X-ray tube current-time products.

Materials and methods: In this IRB-approved prospective study, forty patients (nineteen men, twenty-one women; mean age 69.5 ± 11.2 years) received brain scan at different tube current-time products (300 and 200 mAs) in 64-section multi-detector CT (GE, Discovery CT750 HD). Images were reconstructed with FBP and four levels of ASIR-FBP blending. Two radiologists (please note that our hospital is renowned for its geriatric medicine department, and these two radiologists are more experienced in chronic cerebral vascular disease than in neoplastic disease, so this research did not contain cerebral tumors but as a discussion) assessed all the reconstructed images for visibility of normal structures, lesion conspicuity, image contrast and diagnostic confidence in a blinded and randomized manner. Volume CT dose index (CTDI(vol)) and dose-length product (DLP) were recorded. All the data were analyzed by using SPSS 13.0 statistical analysis software.

Results: There was no statistically significant difference between the image qualities at 200 mAs with 50% ASIR blending technique and 300 mAs with FBP technique (p>.05). While between the image qualities at 200 mAs with FBP and 300 mAs with FBP technique a statistically significant difference (p<.05) was found.

Conclusion: ASIR provided same image quality and diagnostic ability in brain imaging with greater than 30% dose reduction compared with FBP reconstruction technique.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Algorithms*
  • Brain / diagnostic imaging*
  • Brain Diseases / diagnostic imaging*
  • Data Interpretation, Statistical
  • Female
  • Humans
  • Male
  • Middle Aged
  • Radiographic Image Enhancement / methods*
  • Radiographic Image Interpretation, Computer-Assisted / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods*