The potential of stem cells as an in vitro source of red blood cells for transfusion

Cell Stem Cell. 2012 Feb 3;10(2):115-9. doi: 10.1016/j.stem.2012.01.001.


Recent advances have increased excitement about the potential for therapeutic production of red blood cells (RBCs) in vitro. However, generation of RBCs in the large numbers required for transfusion remains a significant challenge. In this article, we summarize recent progress in producing RBCs from various cell sources, and discuss the hurdles that remain for translation into the clinical arena.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Culture Techniques*
  • Cell Proliferation
  • Clinical Trials as Topic
  • Erythrocyte Transfusion*
  • Erythrocytes / cytology*
  • Humans
  • Stem Cells / cytology*