Study on the influence of cranberry extract Żuravit S·O·S(®) on the properties of uropathogenic Escherichia coli strains, their ability to form biofilm and its antioxidant properties

Phytomedicine. 2012 Apr 15;19(6):506-14. doi: 10.1016/j.phymed.2011.12.013. Epub 2012 Feb 4.


Consumption of cranberries is known to exert positive health effects, especially against urinary tract infections. For this reason, presumably, they are widely used in folk medicine. Different aspects of cranberry phenolics activity were studied in individual papers but complex study in this matter is missing. The aim of the present study is to provide complex data concerning various aspects of cranberry extract activity. We studied the effects of subinhibitory concentrations of commercially available extract (Żuravit S·O·S(®)) against two Escherichia coli strains isolated from urine of patients with pyelonephritis. Additionally the main extract anthocyanins were characterized. The activity of extract against lipid peroxidation and its radical scavenging ability were also assessed. Żuravit S·O·S(®) decreased the hydrophobicity of one of the studied E. coli strains, reduced swimming motility and adhesion to epithelial cells of both studied strains, it also limited the ability of bacteria to form biofilm. Expression of curli was not affected by cranberry extract, the assessment of P fimbriae expression was not reliable due to extract-induced agglutination of erythrocytes. Cranberry extract caused filamentation in both studied E. coli strains. It also showed pronounced antioxidant and radical scavenging properties. The properties of the studied cranberry extract show that it could be effectively used in prevention and/or elimination of urinary tract infections, specially the recurrent ones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthocyanins / pharmacology
  • Antioxidants / pharmacology
  • Biofilms / drug effects*
  • Drug Evaluation
  • Escherichia coli Infections / diet therapy*
  • Fruit / chemistry
  • Humans
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Pyelonephritis / drug therapy
  • Urinary Tract Infections / diet therapy
  • Urinary Tract Infections / prevention & control
  • Urine / microbiology
  • Uropathogenic Escherichia coli / drug effects*
  • Uropathogenic Escherichia coli / pathogenicity*
  • Uropathogenic Escherichia coli / physiology
  • Vaccinium macrocarpon / chemistry*


  • Anthocyanins
  • Antioxidants
  • Plant Extracts