A new iridoid glycoside from the roots of Dipsacus asper

Molecules. 2012 Feb 3;17(2):1419-24. doi: 10.3390/molecules17021419.

Abstract

A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4',4''-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ₂₅₋₃₅ induced cell death in PC12 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dipsacaceae / chemistry*
  • Iridoid Glucosides / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • PC12 Cells
  • Plant Roots / chemistry*
  • Rats
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Iridoid Glucosides