Regioselective zincation of indazoles using TMP2Zn and Negishi cross-coupling with aryl and heteroaryl iodides

Chem Commun (Camb). 2012 Mar 11;48(21):2680-2. doi: 10.1039/c2cc17804d. Epub 2012 Feb 3.

Abstract

The metalation of various SEM-protected functionalized indazoles with TMP(2)Zn provides 3-zincated indazoles which undergo palladium-catalyzed Negishi cross-couplings in good yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Indazoles / chemistry*
  • Iodides / chemistry*
  • Palladium / chemistry
  • Piperidines / chemistry*
  • Stereoisomerism
  • Zinc / chemistry*

Substances

  • Indazoles
  • Iodides
  • Piperidines
  • 2,2,6,6-tetramethylpiperidide
  • Palladium
  • Zinc