Abstract
An aptamer microarray was directly fabricated on a MALDI target plate for high-throughput insulin detection. High sensitivities were observed both in standard solutions (5 ng mL(-1), 0.86 nM) and serum sample (20 ng mL(-1), 3.4 nM). This method shows great promise in the field of biomarker detection.
This journal is © The Royal Society of Chemistry 2012
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aptamers, Nucleotide / chemistry*
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Chemistry Techniques, Analytical / methods*
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Gold / chemistry
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Humans
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Insulin / analysis*
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Metal Nanoparticles / chemistry
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Metal Nanoparticles / ultrastructure
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Protein Array Analysis
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*
Substances
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Aptamers, Nucleotide
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Insulin
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Gold