Measurement of Amino-Terminal Propeptide of C-type Natriuretic Peptide in Patients With Idiopathic Short Stature or Isolated Growth Hormone Deficiency

J Pediatr Endocrinol Metab. 2011;24(11-12):989-94. doi: 10.1515/jpem.2011.281.


Objective: To explore the value of amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) in evaluating the effectiveness of therapy with recombinant human growth hormone (rhGH) in patients with idiopathic short stature (ISS) and isolated growth hormone deficiency (IGHD).

Methods: Forty-eight prepubertal children (IGHD = 25, ISS = 23) treated for at least 1 year with rhGH were included. Insulin growth factor-1 (IGF-I) and NTproCNP serum levels were measured before starting treatment and again 6 months later. Twelve months after starting treatment, all patients were assessed and annual growth velocity (GV), height standard deviation score (HTSDS), and gain HTSDS (deltaHTSDS) were recorded.

Results: In the GHD group, positive relationships between GV and change of IGF-I(SDS) (deltaIGF-I(SDS)), GV and change of NTproCNP concentrations (deltaNTproCNP) were found. GH peak value was also positively associated with IGF-I(SDS) and NTproCNP before therapy and deltaIGF-I(SDS) and deltaNTproCNP were positively associated. In the ISS group, GV was associated with only deltaNTproCNP.

Conclusions: NTproCNP is a novel biomarker of growth as levels increase during growth-promoting treatment. Furthermore, IGF-I is also valuable in evaluating the efficacy of rhGH therapy in short stature patients.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Biomarkers / blood
  • Body Height / physiology*
  • Child
  • Drug Monitoring / methods
  • Female
  • Growth Disorders / blood*
  • Growth Disorders / diagnosis*
  • Growth Disorders / drug therapy
  • Human Growth Hormone / administration & dosage
  • Human Growth Hormone / deficiency*
  • Humans
  • Insulin-Like Growth Factor I / deficiency
  • Insulin-Like Growth Factor I / metabolism*
  • Male
  • Natriuretic Peptide, C-Type / blood*
  • Pilot Projects


  • Biomarkers
  • amino-terminal pro-C-type natriuretic peptide, human
  • Human Growth Hormone
  • Natriuretic Peptide, C-Type
  • Insulin-Like Growth Factor I