The male permanent residents of Arkhangelsk were examined during the period of daylight hours minimal duration for the purpose to determine the age-related changes in hormones' level. In the age group of 36-45 years the level recession of progesterone, cortisol and testosterone free fractions against the background of broadening towards higher standard limit of fluctuations of steroid-binding beta-globulin level was demonstrated. In the age group of 46-60 years the rise of cortisol level and tendency to level recession of free thyroxin under thyrotrophic hormone level increase was registered. The hypophysial regulation consisted in lutropin and prolactin level lowering at the age of 36-45 years and in rise of thyrotrophic hormone level at the age of 46-60 years.