Review article: Part one: Goal-directed resuscitation--which goals? Haemodynamic targets

Emerg Med Australas. 2012 Feb;24(1):14-22. doi: 10.1111/j.1742-6723.2011.01516.x. Epub 2012 Jan 17.


The use of appropriate resuscitation targets or end-points may facilitate early detection and appropriate management of shock. There is a fine balance between oxygen delivery and consumption, and when this is perturbed, an oxygen debt is generated. In this narrative review, we explore the value of global haemodynamic resuscitation end-points, including pulse rate, blood pressure, central venous pressure and mixed/central venous oxygen saturations. The evidence supporting the reliability of these parameters as end-points for guiding resuscitation and their potential limitations are evaluated.

Publication types

  • Review

MeSH terms

  • Blood Pressure / physiology
  • Central Venous Pressure / physiology
  • Heart Rate / physiology
  • Humans
  • Oxygen / administration & dosage
  • Oxygen / blood
  • Oxygen Consumption / physiology
  • Resuscitation / methods*
  • Shock, Hemorrhagic / etiology
  • Shock, Hemorrhagic / therapy*
  • Ultrasonography
  • Wounds and Injuries / diagnostic imaging
  • Wounds and Injuries / physiopathology*
  • Wounds and Injuries / therapy*


  • Oxygen