New insight puts CRAF in sight as a therapeutic target

Cancer Discov. 2011 Jul;1(2):98-9. doi: 10.1158/2159-8290.CD-11-0118.

Abstract

By selectively depleting components of the RAF-MEK-ERK pathway in transgenic mice, it is now shown in 2 studies that CRAF is critical for signaling to MEK downstream of oncogenic Kras and that BRAF is not required.

Publication types

  • Comment

MeSH terms

  • Animals
  • Lung Neoplasms / enzymology*
  • Lung Neoplasms / genetics*
  • Proto-Oncogene Proteins c-raf / genetics*
  • Proto-Oncogene Proteins c-raf / metabolism*
  • ras Proteins / genetics*
  • ras Proteins / metabolism*

Substances

  • Proto-Oncogene Proteins c-raf
  • ras Proteins