Ureterosigmoidostomy: long-term results, risk of carcinoma and etiological factors for carcinogenesis

J Urol. 1990 Nov;144(5):1110-4. doi: 10.1016/s0022-5347(17)39670-2.


We followed postoperatively 75 patients who underwent ureterosigmoidostomy between 1942 and 1987. Of the patients 30 were asked to undergo routine examination, including fiberoptic sigmoidoscopy with biopsy and analysis of a urine-feces slurry for nitrate, nitrite and nitrosamines in comparison to 20 control volunteers. After a mean observation of 14 years 7 months (1 to 46 years) 64.5% of the patients had bilaterally normal kidneys without any previous complications, 77.5% of the renal units being normal. Sigmoidoscopic biopsy revealed 3 carcinomas at the ureterocolonic junction resulting in an 8.5 to 10.5-fold increased risk of colon carcinoma compared to the general population. The excretion of nitrite and N-nitrosamines was increased, and nitrate excretion was decreased compared to healthy control volunteers, suggesting endogenous formation of nitrosamines by bacterially reduced nitrate and endogenous amines. The urological long-term results of ureterosigmoidostomy are similar to those of conduits. However, the increased incidence of colon carcinoma is not yet proved to be higher than in conduits.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Colon, Sigmoid / surgery
  • Colonic Neoplasms / epidemiology*
  • Colonic Neoplasms / etiology
  • Follow-Up Studies
  • Humans
  • Nitrates / analysis
  • Nitrites / analysis
  • Nitrosamines / analysis
  • Postoperative Period
  • Risk Factors
  • Time Factors
  • Ureteral Obstruction / epidemiology
  • Ureteral Obstruction / etiology
  • Urinary Diversion / adverse effects*


  • Nitrates
  • Nitrites
  • Nitrosamines