Ginseng as a potential novel addition to the antikeloid weaponry

Phytother Res. 2012 Oct;26(10):1579-80. doi: 10.1002/ptr.4598. Epub 2012 Feb 8.

Abstract

Keloid scars are large protruding claw-shaped lesions that develop beyond the confines of the wound and uniquely appears only in humans. For thousands of years ginseng has been used in the traditional medicine in oriental countries. It occupies a prominent position in the list of the best-selling medicinal herbs in the world. Panax ginseng often called Asian or Korean ginseng, is the most extensively used and the best grade of ginseng and the term of 'ginseng' generally refers to Panax ginseng. Previous studies have revealed that ginseng inhibits NF-kappa B, TGF-β, IL-6, ACE and MMP-2 and these factors play a pivotal role in keloid formation pathogenesis. Therefore it could be reasoned that ginseng could be effective for the treatment of the keloid scars. Clinical studies by topical applications of iPanax notoginseng (800 µg/ml) are warranted.

Publication types

  • Letter

MeSH terms

  • Acetylcholinesterase / metabolism
  • Animals
  • Ginsenosides / pharmacology*
  • Humans
  • Interleukin-6 / antagonists & inhibitors
  • Keloid / drug therapy*
  • Matrix Metalloproteinase 2 / metabolism
  • NF-kappa B / antagonists & inhibitors
  • Panax / chemistry*
  • Transforming Growth Factor beta / antagonists & inhibitors

Substances

  • Ginsenosides
  • Interleukin-6
  • NF-kappa B
  • Transforming Growth Factor beta
  • Acetylcholinesterase
  • MMP2 protein, human
  • Matrix Metalloproteinase 2