The precision of PiCCO® measurements in hypothermic post-cardiac arrest patients

Anaesthesia. 2012 Mar;67(3):236-43. doi: 10.1111/j.1365-2044.2011.06981.x.


The aim of the present study was to determine the precision of the PiCCO(®) system for post-cardiac arrest patients who underwent therapeutic hypothermia. The precision of the measurements for cardiac output, global end-diastolic volume, extravascular lung water and the pulmonary vascular permeability index was assessed using the least significant change; this was regarded as precise when less than 15%. A total of 462 measurement sets were prospectively performed on 88 patients following successful resuscitation after cardiac arrest. Using the mean value of three injections for a measurement, the least significant change for the cardiac output, global end-diastolic volume, extravascular lung water and pulmonary vascular permeability index measurements were found to be 7.8%, 8.5%, 7.8% and 12.1%, respectively. No significant differences between hypothermia (n=150) and non-hypothermia (n=312) were found. The PiCCO-derived variables were found to be precise for post-cardiac arrest patients even under conditions of varying body temperature.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Capillary Permeability
  • Cardiac Output
  • Extravascular Lung Water
  • Female
  • Heart Arrest / physiopathology*
  • Humans
  • Hypothermia, Induced*
  • Male
  • Middle Aged
  • Prospective Studies
  • Stroke Volume
  • Thermodilution*