[Role of stem cells in the pathogenesis of chronic obstructive pulmonary disease and of pulmonary emphysema]

Recenti Prog Med. 2012 Jan;103(1):31-40. doi: 10.1701/1022.11157.
[Article in Italian]


There are only few human translational studies performed in the area of stem cell research in patients with chronic obstructive pulmonary disease (COPD) and/or pulmonary emphysema. Before progress to clinical trials with stem cells we believe that more human translational studies are necessaries, otherwise the clinical rationale would be solely based on limited in vitro and animal studies. In the future, stem cell therapy could be a treatment for this disease. Currently, stem cell therapy is still to be considered as an area of active research, lacking a strong rationale for performing clinical trials in COPD. Although stem cells would be likely to represent a heterogeneous population of cells, the different cell subsets and their importance in the pathogenesis of the different clinical phenotypes need to be fully characterised before progressing to clinical trials. Moreover, the potential side effects of the stem cell therapy are often underestimated. We should not ignore that some of the most deadly neoplasms are arising from stem cells.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Evidence-Based Medicine
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Italy
  • Mesenchymal Stem Cell Transplantation
  • Multicenter Studies as Topic
  • Pulmonary Disease, Chronic Obstructive / etiology
  • Pulmonary Disease, Chronic Obstructive / pathology
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Pulmonary Disease, Chronic Obstructive / surgery*
  • Pulmonary Emphysema / etiology
  • Pulmonary Emphysema / pathology
  • Pulmonary Emphysema / physiopathology
  • Pulmonary Emphysema / surgery*
  • Risk Factors
  • Smoking / adverse effects
  • Stem Cell Transplantation* / adverse effects
  • Stem Cell Transplantation* / ethics
  • Stem Cell Transplantation* / trends
  • Stem Cells*
  • Treatment Outcome