Vasopressin release is enhanced by the Hemocontrol biofeedback system and could contribute to better haemodynamic stability during haemodialysis

Nephrol Dial Transplant. 2012 Aug;27(8):3263-70. doi: 10.1093/ndt/gfr793. Epub 2012 Feb 7.


Background: Haemodialysis with the Hemocontrol biofeedback system (HHD) is associated with improved haemodynamic stability compared with standard haemodialysis (HD) (SHD). Although the beneficial effect of HHD on haemodynamic stability is generally explained by its effect on blood volume, we questioned whether additional factors could play a role. Since HHD is associated with higher initial dialysate sodium concentrations and ultrafiltration (UF) rate, we studied whether the beneficial effect of HHD on haemodynamic stability may be explained by an increased release of the vasoconstrictor arginine vasopressin (AVP).

Methods: Fifteen chronic dialysis patients underwent SHD and HHD in random order. All other treatment factors were identical and patients served as their own control. Plasma levels of AVP were measured pre-dialysis, at 30 and 60 min intra-dialysis and, next, hourly until completion of the dialysis session.

Results: Plasma AVP levels did not change significantly during SHD, whereas AVP levels rose significantly within 30 min after the start of HHD (P < 0.01). AVP levels were significantly higher at 30 and 60 min of HHD in comparison with SHD (P < 0.05). Dialysis hypotension occurred significantly less frequent during HHD than during SHD (P < 0.05).

Conclusions: HHD is associated with higher initial AVP levels compared with SHD. The enhanced release of the vasoconstrictor AVP with HHD could contribute to the lower frequency of dialysis hypotension by facilitating fluid removal during the first part of the dialysis session, permitting lower UF rates during the second half of the dialysis session.

MeSH terms

  • Adult
  • Aged
  • Arginine Vasopressin / blood
  • Arginine Vasopressin / metabolism*
  • Biofeedback, Psychology / methods*
  • Blood Pressure / physiology
  • Blood Volume / physiology
  • Female
  • Hemodynamics / physiology*
  • Humans
  • Hypotension / etiology
  • Hypotension / physiopathology
  • Hypotension / prevention & control
  • Male
  • Middle Aged
  • Osmolar Concentration
  • Renal Dialysis / adverse effects
  • Renal Dialysis / methods*
  • Sodium / blood
  • Time Factors
  • Vasoconstriction / physiology


  • Arginine Vasopressin
  • Sodium