How to activate a gene: decap its associated noncoding RNA

Mol Cell. 2012 Feb 10;45(3):271-3. doi: 10.1016/j.molcel.2012.01.014.


Capped and polyadenylated long noncoding RNAs (lncRNAs) are shown to be degraded by a DCP2-mediated turnover mechanism by Geisler et al. (2012); this provides a new level of regulatory control for inducible genes by lncRNAs.

Publication types

  • Comment

MeSH terms

  • Exoribonucleases / genetics*
  • Gene Expression Regulation, Fungal*
  • RNA Caps / metabolism*
  • RNA Processing, Post-Transcriptional*
  • RNA, Untranslated / metabolism*
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae Proteins / genetics*


  • RNA Caps
  • RNA, Untranslated
  • Saccharomyces cerevisiae Proteins
  • RAT1 protein, S cerevisiae
  • Exoribonucleases