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. 2012 May;142(5):1100-1101.e2.
doi: 10.1053/j.gastro.2012.01.034. Epub 2012 Feb 8.

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

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Free PMC article

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

Swaroop Pendyala et al. Gastroenterology. .
Free PMC article

Abstract

Endotoxemia, characterized by an excess of circulating bacterial wall lipopolysaccharide, is associated with systemic inflammation and the metabolic syndrome. Placing 8 healthy subjects on a Western-style diet for 1 month induced a 71% increase in plasma levels of endotoxin activity (endotoxemia), whereas a prudent-style diet reduced levels by 31%. The Western-style diet might, therefore, contribute to endotoxemia by causing changes in gastrointestinal barrier function or the composition of the microbiota. Endotoxemia might also develop in individuals with gastrointestinal barrier impairment. Therapeutic reagents that reduce endotoxemia might reduce systemic inflammation in patients with gastrointestinal diseases or metabolic syndrome.

Conflict of interest statement

Conflicts of Interest

The authors disclose no conflicts.

Figures

Figure 1
Figure 1
Plasma endotoxin activity levels. Data from 8 individual subjects shown as endotoxin activity units for the Western-style diet (WD) and the prudent-style diet (PD). Paired t tests were used to compare effects of the diets on endotoxin activity levels. The Mann–Whitney sum test was used to compare effects of the 2 diets on endotoxin activity levels. (A) Effect of WD administration. (B) Effect of PD administration. (C) Differences between baseline measures before administration of the 2 diets. (D) Differences between measurements after administration of the 2 diets.

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