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Meta-Analysis
. 2012 May;61(5):411-5.
doi: 10.1007/s00011-012-0447-5. Epub 2012 Feb 11.

The Association Between the Functional PTPN22 1858 C/T and MIF -173 C/G Polymorphisms and Juvenile Idiopathic Arthritis: A Meta-Analysis

Affiliations
Meta-Analysis

The Association Between the Functional PTPN22 1858 C/T and MIF -173 C/G Polymorphisms and Juvenile Idiopathic Arthritis: A Meta-Analysis

Young Ho Lee et al. Inflamm Res. .

Abstract

Background: The aim of this study was to determine whether the protein tyrosine phosphatase nonreceptor 22 (PTPN22) 1858 C/T (rs2476601) and macrophage migration inhibitory factor (MIF) -173 C/G polymorphisms confer susceptibility to juvenile idiopathic arthritis (JIA).

Methods: A meta-analysis was conducted on variant alleles versus common alleles of the PTPN22 1858 C/T and MIF -173 C/G polymorphisms across ten comparative studies, which containing 4,238 JIA patients and 6,012 normal control subjects.

Results: Ten comparative studies, consisting of nine European, and one Turkish population, were included in his meta-analysis. Meta-analysis showed an association between the T allele of the PTPN22 1858 C/T polymorphism and JIA in Europeans [odds ratio (OR) 1.311, 95% confidence interval (CI) 1.205-1.427, P < 1 × 10(-8)]. In addition, meta-analysis revealed an association between the C allele of the MIF -173 C/G polymorphism and JIA in all subjects (OR 1.482, 95% CI 1.202-1.828, P = 2.3 × 10(-4)).

Conclusions: This meta-analysis confirms that the PTPN22 1858 C/T polymorphism is associated with JIA susceptibility in Europeans and shows that the MIF -173 C/G polymorphism may be associated with susceptibility to JIA.

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