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Comment
. 2012 Feb 28;109(9):3199-200.
doi: 10.1073/pnas.1121560109. Epub 2012 Feb 10.

Extracting β-Amyloid From Alzheimer's Disease

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Extracting β-Amyloid From Alzheimer's Disease

Daniel R Dries et al. Proc Natl Acad Sci U S A. .
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Conflict of interest statement

The authors declare no conflict of interest.

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Fig. 1.
Fig. 1.
Peripheral clearance of Aβ. In the brain, Aβ can oligomerize to form higher-order structures, including protofibrils and fibrils. LRP1 shuttles monomeric Aβ across the BBB and into the blood; RAGE is responsible for Aβ influx. sLRP1 and hepatic LRP1 assist in Aβ degradation via several Aβ-degrading enzymes, including NEP, insulin degrading enzyme (IDE), angiotensin converting enzyme (ACE), and plasmin. Sehgal et al. (2) find that WS extract reverses AD pathology by up-regulating sLRP1 and hepatic LRP1, thereby shifting the equilibrium to reduce the total Aβ load and oligomerization.

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