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. 2012 Feb 28;109(9):3199-200.
doi: 10.1073/pnas.1121560109. Epub 2012 Feb 10.

Extracting β-Amyloid From Alzheimer's Disease

Free PMC article

Extracting β-Amyloid From Alzheimer's Disease

Daniel R Dries et al. Proc Natl Acad Sci U S A. .
Free PMC article

Conflict of interest statement

The authors declare no conflict of interest.


Fig. 1.
Fig. 1.
Peripheral clearance of Aβ. In the brain, Aβ can oligomerize to form higher-order structures, including protofibrils and fibrils. LRP1 shuttles monomeric Aβ across the BBB and into the blood; RAGE is responsible for Aβ influx. sLRP1 and hepatic LRP1 assist in Aβ degradation via several Aβ-degrading enzymes, including NEP, insulin degrading enzyme (IDE), angiotensin converting enzyme (ACE), and plasmin. Sehgal et al. (2) find that WS extract reverses AD pathology by up-regulating sLRP1 and hepatic LRP1, thereby shifting the equilibrium to reduce the total Aβ load and oligomerization.

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