Rice protein improves adiposity, body weight and reduces lipids level in rats through modification of triglyceride metabolism

Lipids Health Dis. 2012 Feb 13;11:24. doi: 10.1186/1476-511X-11-24.


Background: To elucidate whether rice protein can possess a vital function in improving lipids level and adiposity, the effects of rice proteins extracted by alkaline (RP-A) and α-amylase (RP-E) on triglyceride metabolism were investigated in 7-week-old male Wistar rats fed cholesterol-enriched diets for 2 weeks, as compared with casein (CAS).

Results: Compared with CAS, plasma concentrations of glucose and lipids were significantly reduced by RP-feeding (P < 0.05), as well as hepatic accumulation of lipids (P < 0.05). RP-A and RP-E significantly depressed the hepatic activities of fatty acid synthase (FAS), glucose 6-phosphate dehydrogenase (G6PD) and malate dehydrogenase (MDH) (P < 0.05), whereas the activities of lipoprotein lipase (PL) and hepatic lipase (HL) were significantly stimulated (P < 0.05), as compared to CAS. Neither lipids level nor activities of enzymes were different between RP-A and RP-E (P > 0.05). There was a significant positive correlation between protein digestibility and deposit fat (r = 0.8567, P < 0.05), as well as the plasma TG concentration (r = 0.8627, P < 0.05).

Conclusions: The present study demonstrates that rice protein can modify triglyceride metabolism, leading to an improvement of body weight and adiposity. Results suggest that the triglyceride-lowering action as well as the potential of anti-adiposity induced by rice protein is attributed to upregulation of lipolysis and downregulation of lipogenesis, and the lower digestibility of rice protein may be the main modulator responsible for the lipid-lowering action.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiposity / drug effects*
  • Alanine Transaminase / blood
  • Amino Acids / blood
  • Animals
  • Anti-Obesity Agents / isolation & purification
  • Anti-Obesity Agents / pharmacology*
  • Aspartate Aminotransferases / blood
  • Diet, High-Fat
  • Feces / chemistry
  • Lipids / blood*
  • Lipogenesis / drug effects
  • Lipolysis / drug effects
  • Lipotropic Agents / isolation & purification
  • Lipotropic Agents / pharmacology*
  • Liver / drug effects
  • Liver / enzymology
  • Liver / metabolism
  • Male
  • Oryza / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Proteins / isolation & purification
  • Plant Proteins / pharmacology*
  • Rats
  • Rats, Wistar
  • Triglycerides / metabolism*
  • Weight Loss / drug effects*


  • Amino Acids
  • Anti-Obesity Agents
  • Lipids
  • Lipotropic Agents
  • Plant Extracts
  • Plant Proteins
  • Triglycerides
  • Aspartate Aminotransferases
  • Alanine Transaminase