Therapeutic strategies in epithelial ovarian cancer

J Exp Clin Cancer Res. 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14.


Ovarian cancer is the most lethal gynecologic malignancy. It appears that the vast majority of what seem to be primary epithelial ovarian and primary peritoneal carcinomas is, in fact, secondary from the fimbria, the most distal part of the fallopian tube. Treatment of epithelial ovarian cancer is based on the combination of cytoreductive surgery and combination chemotherapy using taxane and platinum. Although clear cell type is categorized in indolent type, it is known to show relatively strong resistance to carboplatin and paclitaxel regimen and thus poor prognosis compared to serous adenocarcinoma, especially in advanced stages. Irinotecan plus cisplatin therapy may effective for the clear cell adenocarcinoma. The larger expectation for improved prognosis in ovarian carcinoma is related to the use of the new biological agents. One of the most investigated and promising molecular targeted drugs in ovarian cancer is bevacizumab, a monoclonal antibody directed against VEGF. PARP inhibitor is another one. A few recent studies demonstrated positive results of bevacizumab on progression-free survival in ovarian cancer patients, however, investigation of molecular targeting drugs in patients with ovarian cancer are still underway.

Publication types

  • Review

MeSH terms

  • Bridged-Ring Compounds / therapeutic use*
  • Carcinoma, Ovarian Epithelial
  • Combined Modality Therapy
  • Disease-Free Survival
  • Drug Resistance, Neoplasm
  • Female
  • Humans
  • Molecular Targeted Therapy
  • Neoplasms, Glandular and Epithelial / classification
  • Neoplasms, Glandular and Epithelial / pathology*
  • Neoplasms, Glandular and Epithelial / therapy*
  • Ovarian Neoplasms / classification
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / therapy*
  • Peritoneal Neoplasms / diagnosis
  • Peritoneal Neoplasms / pathology*
  • Platinum / therapeutic use*
  • Prognosis
  • Taxoids / therapeutic use*


  • Bridged-Ring Compounds
  • Taxoids
  • taxane
  • Platinum