Resolve, revise, and relax: the 3 Rs of B cell repertoire adjustment

Immunol Lett. 2012 Mar 30;143(1):2-8. doi: 10.1016/j.imlet.2012.01.014. Epub 2012 Feb 6.


Competition for limited, cell extrinsic survival factors is a general feature of peripheral selection checkpoints involved in B lymphocyte maturation and activation. Perhaps the best-characterized example involves BLyS (B lymphocyte stimulator), which modulates the size and composition of mature naïve B cell pools, but evidence for analogous competitive checkpoints is emerging for both germinal center B cells and plasma cells. Here we discuss how deliberate alteration of BLyS levels might be used to manipulate B cell repertoire selection in order to restore self-tolerance in autoimmunity, remodel the repertoire to accommodate neo-self antigens introduced through transplantation and gene therapy, or expand repertoire diversity to reveal novel, therapeutically useful specificities.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens / immunology
  • Autoimmunity
  • B-Cell Activating Factor / immunology
  • B-Lymphocytes / immunology*
  • Homeostasis
  • Humans
  • Immune Tolerance


  • Antigens
  • B-Cell Activating Factor