Protective activity of processed tomato products on postprandial oxidation and inflammation: a clinical trial in healthy weight men and women

Mol Nutr Food Res. 2012 Apr;56(4):622-31. doi: 10.1002/mnfr.201100649. Epub 2012 Feb 14.

Abstract

Scope: This study was designed to evaluate the ability of tomato rich in lycopene to modify postprandial oxidative stress, inflammation, and endothelial function in healthy weight individuals.

Methods and results: Twelve women and 13 men (mean age = 27 ± 8 years; mean body mass index= 22 ± 2) consumed high-fat meals known to induce postprandial oxidative stress on two separate occasions containing either processed tomato product or non-tomato alternative. Blood samples were collected at 0, 30, 60, 90, 120 min, then hourly until 360 min. Flow-mediated dilation (FMD) was performed at 0 and 210 min. Endpoints included changes in glucose, insulin, lipids, oxidized low-density lipoprotein (OxLDL), inflammatory cytokines, and FMD. Both meals induced increases in plasma glucose, insulin, and lipid concentrations (p < 0.05). A trend for higher triglycerides at >240 min was observed after the tomato meal (p = 0.006). Tomato significantly attenuated high-fat meal-induced LDL oxidation (p < 0.05) and rise in interleukin-6 (p < 0.0001), a proinflammatory cytokine and inflammation marker.

Conclusion: The data indicate that consuming tomato products with a meal attenuates postprandial lipemia-induced oxidative stress and associated inflammatory response. The relevance of OxLDL and inflammation to vascular injury suggests a potentially important protective role of tomato in reducing cardiovascular disease risk. ClinicalTrials.gov Registration number - NCT00966550.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Cross-Over Studies
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / physiopathology
  • Endpoint Determination
  • Female
  • Humans
  • Hyperlipidemias / physiopathology
  • Hyperlipidemias / therapy
  • Inflammation / physiopathology
  • Inflammation / prevention & control*
  • Insulin / blood
  • Interleukin-6 / blood
  • Lipoproteins, LDL / blood
  • Lycopersicon esculentum / chemistry*
  • Male
  • Oxidation-Reduction
  • Oxidative Stress / drug effects*
  • Postprandial Period / drug effects*
  • Young Adult

Substances

  • Blood Glucose
  • Insulin
  • Interleukin-6
  • Lipoproteins, LDL
  • oxidized low density lipoprotein

Associated data

  • ClinicalTrials.gov/NCT00966550