[Enzymatic activity of thymidine kinase of herpes simlex virus strain resistant to H-phosphonates of Acv]

Bioorg Khim. Sep-Oct 2011;37(5):627-30. doi: 10.1134/s1068162011050074.
[Article in Russian]

Abstract

Cloned laboratory mutants of herpes simplex virus type I resistant to acycloguanosine H-phosphonate have been investigated. For all clones were shown that mutations resulted to increasing of sensitivity to acting of sidofovir. Thymidine kinase of mutant viruses partially preserves the ability to phosphorilate thymidine, but loses the ability to phosphorilate BVDU.

Publication types

  • English Abstract

MeSH terms

  • Acyclovir / analogs & derivatives*
  • Acyclovir / pharmacology
  • Animals
  • DNA-Directed DNA Polymerase / genetics
  • DNA-Directed DNA Polymerase / metabolism*
  • Drug Resistance, Viral / drug effects*
  • Herpesvirus 1, Human / drug effects*
  • Herpesvirus 1, Human / enzymology*
  • Humans
  • Mutation
  • Organophosphonates / pharmacology*
  • Thymidine Kinase / chemistry*
  • Thymidine Kinase / genetics
  • Vero Cells

Substances

  • Organophosphonates
  • acycloguanosine H-phosphonate
  • Thymidine Kinase
  • DNA-Directed DNA Polymerase
  • Acyclovir