Paradoxical sleep deprivation induces muscle atrophy

Muscle Nerve. 2012 Mar;45(3):431-3. doi: 10.1002/mus.22322.


Introduction: Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleep-deprived rats.

Methods: Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle.

Results: PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels.

Conclusion: PSD induces hormonal alterations that may mediate muscle atrophy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Disease Models, Animal
  • Male
  • Muscular Atrophy / etiology*
  • Rats
  • Rats, Wistar
  • Sleep Deprivation / complications*