Cortical structural abnormalities in deficit versus nondeficit schizophrenia

Schizophr Res. 2012 Apr;136(1-3):51-4. doi: 10.1016/j.schres.2012.01.030. Epub 2012 Feb 13.


Objective: To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia.

Method: A three-dimensional structural MRI sequence was used to conduct morphometric assessments of cortical and subcortical regions in deficit and nondeficit outpatients with schizophrenia and healthy controls.

Results: The superior prefrontal and superior and middle temporal gyral gray matter volumes were significantly smaller in the deficit versus the nondeficit group and normal control groups. There were no significant group differences in examined subcortical structures.

Conclusion: People with deficit schizophrenia are characterized by selective reductions in the prefrontal and temporal cortex.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Brain / pathology*
  • Female
  • Humans
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neural Pathways / pathology
  • Neural Pathways / physiology
  • Psychiatric Status Rating Scales
  • Schizophrenia / pathology*
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*
  • Young Adult