Modular regulatory principles of large non-coding RNAs

Nature. 2012 Feb 15;482(7385):339-46. doi: 10.1038/nature10887.


It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein. The mammalian genome is extensively transcribed, giving rise to thousands of non-coding transcripts. Whether all of these transcripts are functional is debated, but it is evident that there are many functional large non-coding RNAs (ncRNAs). Recent studies have begun to explore the functional diversity and mechanistic role of these large ncRNAs. Here we synthesize these studies to provide an emerging model whereby large ncRNAs might achieve regulatory specificity through modularity, assembling diverse combinations of proteins and possibly RNA and DNA interactions.

Publication types

  • Review

MeSH terms

  • Chromatin / genetics
  • Gene Expression Regulation
  • RNA, Untranslated / analysis
  • RNA, Untranslated / genetics
  • RNA, Untranslated / metabolism*
  • RNA-Binding Proteins / metabolism


  • Chromatin
  • RNA, Untranslated
  • RNA-Binding Proteins