Management of acute coronary syndrome: achievements and goals still to pursue. Novel developments in diagnosis and treatment

J Intern Med. 2012 Jun;271(6):521-36. doi: 10.1111/j.1365-2796.2012.02533.x. Epub 2012 Mar 26.


Acute coronary syndromes contribute a substantial part of the global disease burden. To realize a reduction in mortality and morbidity, the management of patients with these conditions involves the integration of several different approaches. Timely delivery of appropriate care is a key factor, as the beneficial effect of reperfusion is greatest when performed as soon as possible. Innovations in antithrombotic therapy have also contributed significantly to improvements in the prevention of ischaemic complications. However, with the use of such treatment, an increase in the risk of bleeding is inevitable. Therefore, the greatest challenge is now to obtain an optimal balance between the prevention of ischaemic complications and the risk of bleeding. In this regard, identification of patients at highest risk of either one is essential.

Publication types

  • Review

MeSH terms

  • Acute Coronary Syndrome / diagnosis*
  • Acute Coronary Syndrome / drug therapy
  • Acute Coronary Syndrome / mortality
  • Acute Coronary Syndrome / therapy*
  • Angioplasty, Balloon, Coronary / methods
  • Clinical Trials as Topic
  • Early Diagnosis
  • Fibrinolytic Agents / administration & dosage
  • Fibrinolytic Agents / adverse effects
  • Fibrinolytic Agents / therapeutic use*
  • Hemorrhage / chemically induced
  • Hemorrhage / prevention & control
  • Humans
  • Myocardial Reperfusion / methods*
  • Risk Assessment
  • Time Factors
  • Treatment Outcome


  • Fibrinolytic Agents