aSIRTing control over cancer stem cells

Cancer Cell. 2012 Feb 14;21(2):140-2. doi: 10.1016/j.ccr.2012.01.014.


Cancer stem cells lie at the root of chronic myelogenous leukemia (CML) and mediate its continued growth. Their resistance to current therapies results in an inability to eradicate the disease. In this issue of Cancer Cell, Li et al. identify SIRT1 as a new target for eliminating CML cancer stem cells.

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