Glycine decarboxylase cleaves a "malignant" metabolic path to promote tumor initiation

Cancer Cell. 2012 Feb 14;21(2):143-5. doi: 10.1016/j.ccr.2012.01.019.


Tumor-initiating cells (TICs) are thought to be critical for promoting tumorigenesis. In a recent Cell article, Zhang and colleagues found that non-small cell lung cancer TICs overexpress the metabolic enzyme glycine decarboxylase, which leads to increases in pyrimidine synthesis and is critical for proliferation and tumor initiation.

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