Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

P J Kang; J Ostermann; J Shilling; W Neupert; E A Craig; N Pfanner

doi:10.1038/348137a0

Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins

Nature. 1990 Nov 8;348(6297):137-43. doi: 10.1038/348137a0.

Authors

P J Kang¹, J Ostermann, J Shilling, W Neupert, E A Craig, N Pfanner

Affiliation

¹ Department of Physiological Chemistry, University of Wisconsin, Madison 53706.

PMID: 2234077
DOI: 10.1038/348137a0

Abstract

By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Biological Transport
Cell Compartmentation
Cloning, Molecular
DNA Mutational Analysis
Fungal Proteins
HSP70 Heat-Shock Proteins*
Heat-Shock Proteins / physiology*
Mitochondria / physiology*
Mutation
Protein Conformation
Protein Precursors / metabolism
Protein Processing, Post-Translational
Protozoan Proteins*

Substances

Fungal Proteins
HSP70 Heat-Shock Proteins
Heat-Shock Proteins
Protein Precursors
Protozoan Proteins
mtp70 protein, Trypanosoma cruzi