The use and misuse of oxygen during the neonatal period

Clin Perinatol. 2012 Mar;39(1):165-76. doi: 10.1016/j.clp.2011.12.014. Epub 2012 Jan 9.


This article describes aerobic metabolism, oxygen free radicals, antioxidant defenses, oxidative stress, inflammatory response and redox signaling, the fetal to neonatal transition, arterial oxygen saturation, oxygen administration in the delivery room, oxygen during neonatal care in the NICU, evolving oxygen needs in the first few weeks of life, and complications that can occur when infants go home from the hospital on oxygen.

Publication types

  • Review

MeSH terms

  • Antioxidants / metabolism
  • Free Radicals / metabolism
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / metabolism
  • Infant, Newborn, Diseases / therapy*
  • Intensive Care Units, Neonatal*
  • Oxidative Stress*
  • Oxygen / blood
  • Oxygen Inhalation Therapy / adverse effects
  • Oxygen Inhalation Therapy / methods*


  • Antioxidants
  • Free Radicals
  • Oxygen