Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course

Inger-Lise Mero; Cathrine Smestad; Benedicte A Lie; Åslaug R Lorentzen; Leiv Sandvik; Nils Inge Landrø; Jan H Aarseth; Kjell-Morten Myhr; Elisabeth G Celius; Hanne F Harbo

doi:10.1016/j.jneuroim.2012.01.011

Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course

J Neuroimmunol. 2012 Mar;244(1-2):107-10. doi: 10.1016/j.jneuroim.2012.01.011. Epub 2012 Feb 15.

Authors

Inger-Lise Mero¹, Cathrine Smestad, Benedicte A Lie, Åslaug R Lorentzen, Leiv Sandvik, Nils Inge Landrø, Jan H Aarseth, Kjell-Morten Myhr, Elisabeth G Celius, Hanne F Harbo

Affiliation

¹ Department of Neurology, Oslo University Hospital, Ullevål, N-0407 Oslo, Norway. i.l.mero@medisin.uio.no

PMID: 22341604
DOI: 10.1016/j.jneuroim.2012.01.011

Abstract

Brain-derived neurotrophic factor (BDNF) has been proposed a protective role in multiple sclerosis (MS) in several studies. The val(66)met polymorphism alters the function of the BDNF protein, and has along with rs56164415 previously been reported to be associated with MS. We genotyped BDNF SNPs val(66)met and rs56164415 in 2149 Norwegian MS patients and 2747 healthy controls. No association was found for any of the SNPs to disease susceptibility or any clinical or demographic parameters including sex, age at onset, disease course, disease severity and cognitive impairment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Age of Onset
Brain-Derived Neurotrophic Factor / genetics*
Disease Progression
Female
Genetic Association Studies*
Genetic Predisposition to Disease*
Humans
Male
Methionine / genetics
Multiple Sclerosis / epidemiology
Multiple Sclerosis / genetics*
Norway / epidemiology
Polymorphism, Genetic*
Valine / genetics

Substances

Brain-Derived Neurotrophic Factor
Methionine
Valine