Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course

J Neuroimmunol. 2012 Mar;244(1-2):107-10. doi: 10.1016/j.jneuroim.2012.01.011. Epub 2012 Feb 15.


Brain-derived neurotrophic factor (BDNF) has been proposed a protective role in multiple sclerosis (MS) in several studies. The val(66)met polymorphism alters the function of the BDNF protein, and has along with rs56164415 previously been reported to be associated with MS. We genotyped BDNF SNPs val(66)met and rs56164415 in 2149 Norwegian MS patients and 2747 healthy controls. No association was found for any of the SNPs to disease susceptibility or any clinical or demographic parameters including sex, age at onset, disease course, disease severity and cognitive impairment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Brain-Derived Neurotrophic Factor / genetics*
  • Disease Progression
  • Female
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Methionine / genetics
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*
  • Norway / epidemiology
  • Polymorphism, Genetic*
  • Valine / genetics


  • Brain-Derived Neurotrophic Factor
  • Methionine
  • Valine