Cirrhosis due to chronic hepatitis E infection in a child post-bone marrow transplant

Ugur Halac; Kathie Béland; Pascal Lapierre; Natacha Patey; Pierre Ward; Julie Brassard; Alain Houde; Fernando Alvarez

doi:10.1016/j.jpeds.2012.01.028

Cirrhosis due to chronic hepatitis E infection in a child post-bone marrow transplant

J Pediatr. 2012 May;160(5):871-4.e1. doi: 10.1016/j.jpeds.2012.01.028. Epub 2012 Feb 16.

Authors

Ugur Halac¹, Kathie Béland, Pascal Lapierre, Natacha Patey, Pierre Ward, Julie Brassard, Alain Houde, Fernando Alvarez

Affiliation

¹ Department of Pediatrics, Université de Montréal, Quebec, Canada. ugur.halac@umontreal.ca

PMID: 22341950
DOI: 10.1016/j.jpeds.2012.01.028

Abstract

Chronic hepatitis E virus (HEV) infection occurs in immunosuppressed adults. We detected HEV ribonucleic acid in serum of an adolescent patient who had undergone bone marrow transplantation and subsequently presented with persistently increased aminotransferases and histologic chronic hepatitis, and eventually developed cirrhosis. Phylogenetic analysis revealed these HEV strains were similar to swine genotype 3a, suggesting a possible zoonosis.

Publication types

Case Reports

MeSH terms

Adolescent
Antiviral Agents / therapeutic use
Biopsy, Needle
Bone Marrow Transplantation / adverse effects*
Bone Marrow Transplantation / immunology
Chronic Disease
Disease Progression
Follow-Up Studies
Hepatitis E / diagnosis*
Hepatitis E / drug therapy
Hepatitis E / immunology
Hepatitis E virus / drug effects
Hepatitis E virus / isolation & purification
Humans
Immunocompromised Host*
Immunohistochemistry
Liver Cirrhosis / pathology
Liver Cirrhosis / virology*
Liver Function Tests
Male
Postoperative Complications / diagnosis
Postoperative Complications / therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma / surgery*
Risk Assessment
Severity of Illness Index
Transaminases / metabolism

Substances

Antiviral Agents
Transaminases