Epigenetic and epigenomic variation in Arabidopsis thaliana

Trends Plant Sci. 2012 Mar;17(3):149-54. doi: 10.1016/j.tplants.2012.01.001. Epub 2012 Feb 17.


Arabidopsis thaliana (Arabidopsis) is ideally suited for studies of natural phenotypic variation. This species has also provided an unparalleled experimental system to explore the mechanistic link between genetic and epigenetic variation, especially with regard to cytosine methylation. Using high-throughput sequencing methods, genotype to epigenotype to phenotype observations can now be extended to plant populations. We review the evidence for induced and spontaneous epigenetic variants that have been identified in Arabidopsis in the laboratory and discuss how these experimental observations could explain existing variation in the wild.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Alleles
  • Animals
  • Arabidopsis / genetics*
  • Epigenesis, Genetic*
  • Genome, Plant*
  • Humans
  • Mutation