Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes
- PMID: 22342624
- DOI: 10.1016/j.bmcl.2012.01.070
Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes
Abstract
A new acetylenic acid, (10E,14Z)-9-oxooctadeca-10,14-dien-12-ynoic acid (1), was isolated from the edible mushroom Chanterelle (Cantharellus cibarius), together with a known acetylenic acid, (10E,14Z)-9-hydroxyoctadeca-10,14-dien-12-ynoic acid (2) and their structures were determined through analysis of NMR and mass data. The new acetylenic acid (1) specifically activated peroxisome proliferator-activated receptor (PPAR)-γ with an EC(50) value of 1.88 μM as measured by a reporter gene assay. Expression of PPAR-γ target genes were significantly altered as well, supporting the hypothesis that compound 1 is a PPAR-γ potential agonist that regulates transcription of the PPAR-γ target genes.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
-
A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata.Planta Med. 2009 Jun;75(8):803-7. doi: 10.1055/s-0029-1185386. Epub 2009 Feb 25. Planta Med. 2009. PMID: 19242902
-
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist inhibits transforming growth factor-beta1 and matrix production in human dermal fibroblasts.J Plast Reconstr Aesthet Surg. 2010 Jul;63(7):1209-16. doi: 10.1016/j.bjps.2009.06.032. Epub 2009 Jul 18. J Plast Reconstr Aesthet Surg. 2010. PMID: 19617014
-
PAR-1622 is a selective peroxisome proliferator-activated receptor gamma partial activator with preserved antidiabetic efficacy and broader safety profile for fluid retention.Arch Pharm Res. 2009 May;32(5):721-7. doi: 10.1007/s12272-009-1511-8. Epub 2009 May 27. Arch Pharm Res. 2009. PMID: 19471887
-
Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications.Vascul Pharmacol. 2006 Jul;45(1):19-28. doi: 10.1016/j.vph.2005.11.014. Epub 2006 Jun 16. Vascul Pharmacol. 2006. PMID: 16782410 Review.
-
Potential for peroxisome proliferator-activated receptor-gamma agonists in progression: beyond metabolism.Curr Opin Nephrol Hypertens. 2008 May;17(3):282-5. doi: 10.1097/MNH.0b013e3282f9b1c0. Curr Opin Nephrol Hypertens. 2008. PMID: 18408479 Review.
Cited by
-
Rapid Characterization of Chemical Components in Edible Mushroom Sparassis crispa by UPLC-Orbitrap MS Analysis and Potential Inhibitory Effects on Allergic Rhinitis.Molecules. 2019 Aug 20;24(16):3014. doi: 10.3390/molecules24163014. Molecules. 2019. PMID: 31434231 Free PMC article.
-
Nutritional, Nutraceutical, and Medicinal Potential of Cantharellus cibarius Fr.: A Comprehensive Review.Food Sci Nutr. 2024 Dec 13;13(1):e4641. doi: 10.1002/fsn3.4641. eCollection 2025 Jan. Food Sci Nutr. 2024. PMID: 39803245 Free PMC article. Review.
-
The alkynyl-containing compounds from mushrooms and their biological activities.Nat Prod Bioprospect. 2023 Nov 10;13(1):50. doi: 10.1007/s13659-023-00416-w. Nat Prod Bioprospect. 2023. PMID: 37946001 Free PMC article. Review.
-
Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia.Molecules. 2020 Apr 23;25(8):1972. doi: 10.3390/molecules25081972. Molecules. 2020. PMID: 32340227 Free PMC article. Review.
-
Comparative studies of immobilized lipase- and acid-catalyzed fatty acid methyl ester synthesis for seed lipid analysis.Food Sci Biotechnol. 2016 Jun 30;25(3):771-776. doi: 10.1007/s10068-016-0131-6. eCollection 2016. Food Sci Biotechnol. 2016. PMID: 30263335 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Chemical Information
Medical
