Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatment

Clin Biochem. 2012 Apr;45(6):509-11. doi: 10.1016/j.clinbiochem.2012.02.001. Epub 2012 Feb 10.


Objective: We have determined Coenzyme Q(10) (CoQ(10)) levels in salivary cells (SCs) and mononuclear blood cells (BMCs) from Fibromyalgia (FM), and we study the influence of oral CoQ(10) supplementation on cells levels and clinical symptoms.

Methods: CoQ(10) was determined by high-performance liquid chromatography (HPLC). Ten patients were supplemented daily with 300 mg of CoQ(10) during 3 months.

Results: CoQ(10) were reduced in both cell models. Oral supplementation showed an improvement in clinical symptoms and restored levels.

Conclusions: Patients with FM showed an important dysfunction in CoQ(10) levels and might benefit from oral supplementation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Dietary Supplements
  • Fibromyalgia / blood*
  • Fibromyalgia / drug therapy
  • Fibromyalgia / pathology
  • Humans
  • Leukocytes, Mononuclear / metabolism*
  • Middle Aged
  • Salivary Ducts / metabolism
  • Salivary Ducts / pathology*
  • Treatment Outcome
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / deficiency
  • Ubiquinone / pharmacokinetics
  • Ubiquinone / therapeutic use
  • Vitamins / pharmacokinetics
  • Vitamins / therapeutic use*


  • Vitamins
  • Ubiquinone
  • coenzyme Q10