Airway complications after lung transplantation: long-term outcome of silicone stenting

Respiration. 2012;83(3):245-52. doi: 10.1159/000334905. Epub 2012 Feb 15.

Abstract

Background: Airway complications remain a significant cause of morbidity after lung transplantation. The majority of the centres that have published their results have used metal stents.

Objectives: We report the long-term outcome of silicone stenting and subsequent stent removal in lung transplant recipients with stenotic airway complications.

Method: From 1990 to 2008, 279 patients received 88 single, 170 double, and 21 heart-and-lung transplantations. Of 470 anastomoses at risk, 44 airway complications developed and were treated in 35 patients. Six lesions were treated with Nd:YAG laser and balloon dilatations only. Thirty-two silicone stents of Hood or Dumont type were inserted in 27 patients.

Results: Symptoms were relieved and FEV(1) increased in all patients (median 0.7 litres, range 0.1-1.8 litres, p < 0.0001). In 8 patients, stents had to be repositioned or reinserted, in 19 patients only one insertion and one removal procedure were necessary. One patient suffered a serious complication with haemorrhage and pneumonectomy, 3 patients had minor airway wall injuries resolving spontaneously. Six patients died with the stents from causes not related to the airway complications. Twenty-five stents could be removed after a median of 6 months (range 1-22) in 21 patients, and 22 airways remained patent. Median FEV(1) was 2.3 litres immediately after stent removal, and remained 2.3 litres after 24 months.

Conclusion: Stenotic airway complications after lung transplantation can be successfully treated with silicone stents, which can ultimately be removed, leaving a patent airway.

MeSH terms

  • Adult
  • Algorithms
  • Bronchial Diseases / etiology
  • Bronchial Diseases / therapy*
  • Constriction, Pathologic / etiology
  • Constriction, Pathologic / therapy*
  • Female
  • Follow-Up Studies
  • Forced Expiratory Volume
  • Humans
  • Lung Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Silicones
  • Stents / statistics & numerical data*
  • Treatment Outcome
  • Young Adult

Substances

  • Silicones