(D, L) polylactide microspheres as embolic agent. A preliminary study

Neuroradiology. 1990;32(4):311-5. doi: 10.1007/BF00593051.


Owing to their shape, accurately calibrated microspheres appear to be very suitable material for distal embolization. Moreover, the biocompatible (D, L) polyactide (PLA) microspheres possess two other valuable advantages: easy adjustment of their biodegradation rate, and incorporation of chemotherapeutic agents during their production. The authors describe the preparation of these (D, L) PLA microspheres and their clinical applications as a preliminary step to arterial chemoembolization.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biocompatible Materials
  • Carcinoma, Renal Cell / secondary
  • Carcinoma, Renal Cell / therapy
  • Embolization, Therapeutic* / methods
  • Female
  • Humans
  • Meningeal Neoplasms / therapy
  • Meningioma / therapy
  • Microspheres
  • Middle Aged
  • Particle Size
  • Polyesters / chemical synthesis
  • Polyesters / therapeutic use*
  • Spinal Neoplasms / secondary
  • Spinal Neoplasms / therapy
  • Sterilization


  • Biocompatible Materials
  • Polyesters
  • poly(lactide)