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. 2012 Feb;9(2):385-93.
doi: 10.1002/cbdv.201100061.

2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7

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2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7

Yu Wang et al. Chem Biodivers. 2012 Feb.

Abstract

Five new diketopiperazines, prenylcyclotryprostatin B (1), 20-hydroxycyclotryprostatin B (2), 9-hydroxyfumitremorgin C (3), 6-hydroxytryprostatin B (4), and spirogliotoxin (5), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with nine known compounds, 6-14. Their structures were elucidated by spectroscopic methods, and their antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were assessed in vitro. Compounds 10, 12, and 13 exhibited significant cell growth-inhibitory activities against U937 cell line, with the IC(50) values of 1.8, 0.2, and 0.5 μM, respectively.

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