Conductive hydrogels: mechanically robust hybrids for use as biomaterials

Macromol Biosci. 2012 Apr;12(4):494-501. doi: 10.1002/mabi.201100490. Epub 2012 Feb 17.


A hybrid system for producing conducting polymers within a doping hydrogel mesh is presented. These conductive hydrogels demonstrate comparable electroactivity to conventional conducting polymers without requiring the need for mobile doping ions which are typically used in literature. These hybrids have superior mechanical stability and a modulus significantly closer to neural tissue than materials which are commonly used for medical electrodes. Additionally they are shown to support the attachment and differentiation of neural like cells, with improved interaction when compared to homogeneous hydrogels. The system provides flexibility such that biologic incorporation can be tailored for application.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / pharmacology
  • Cell Adhesion / drug effects
  • Electric Conductivity
  • Electrochemical Techniques
  • Electrodes
  • Heparin / analogs & derivatives*
  • Humans
  • Hydrogels / chemical synthesis*
  • Hydrogels / pharmacology
  • Materials Testing
  • Methacrylates / chemistry
  • Neurons / drug effects
  • PC12 Cells
  • Photoelectron Spectroscopy
  • Polymerization
  • Polyvinyl Alcohol / chemistry*
  • Rats
  • Tissue Engineering


  • Biocompatible Materials
  • Hydrogels
  • Methacrylates
  • Polyvinyl Alcohol
  • Heparin