[Establishment of tree shrew chronic morphine dependent model]

Dongwuxue Yanjiu. 2012 Feb;33(1):14-8. doi: 10.3724/SP.J.1141.2012.01014.
[Article in Chinese]


The clinical use of morphine to reduce pain is limited because of its drug tolerance, dependence and addiction. In the present study, the tree shrews (Tupaia belangeri chinensis) developed morphine tolerance and chronic morphine dependence by morphine injections with increasing doses (5, 10, 15, 20 mg/kg body weight for 7 days). Meanwhile, the naloxone (1.25 mg/kg body weight)-induced conditioned place aversion (CPA) and the withdrawal symptom were also found. The tree shrew model of chronic morphine dependence can be used to investigate the withdrawal symptoms and to select potential withdrawal symptoms reducing drugs in the future.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal
  • Disease Models, Animal*
  • Humans
  • Male
  • Morphine / administration & dosage
  • Morphine / adverse effects*
  • Morphine Dependence / etiology
  • Morphine Dependence / physiopathology*
  • Morphine Dependence / psychology
  • Pain / drug therapy*
  • Substance Withdrawal Syndrome / physiopathology*
  • Substance Withdrawal Syndrome / psychology
  • Tupaia*


  • Morphine