Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury

J Leukoc Biol. 2012 Jul;92(1):75-82. doi: 10.1189/jlb.1011530. Epub 2012 Feb 17.


Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus-host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis*
  • Humans
  • Immunity, Innate*
  • Influenza, Human / immunology*
  • Influenza, Human / pathology*
  • Influenza, Human / virology
  • Lung Injury*
  • Orthomyxoviridae / pathogenicity*
  • Virus Replication*