The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks

Genome Biol. 2012 Feb 20;13(2):239. doi: 10.1186/gb-2012-13-2-239.

Abstract

Alcoholism is a significant public health problem. A picture of the genetic architecture underlying alcohol-related phenotypes is emerging from genome-wide association studies and work on genetically tractable model organisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alcoholism / genetics*
  • Animals
  • Disease Models, Animal
  • Drosophila / genetics*
  • Ethanol / metabolism*
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Malate Dehydrogenase / genetics
  • Malate Dehydrogenase / metabolism
  • Mice
  • Phenotype
  • Quantitative Trait Loci / genetics*

Substances

  • Ethanol
  • Malate Dehydrogenase