[Nutrition and miscarriages: a literature review]

Gynecol Obstet Fertil. 2012 Mar;40(3):162-9. doi: 10.1016/j.gyobfe.2012.01.004. Epub 2012 Feb 18.
[Article in French]


Miscarriage concerns approximately 15% of pregnancies and recurrent fetal loss (RFL) constitute a particular situation concerning approximately 1% of women. The etiologic inquiry is often disappointing. Nutritional factors represent a promising aspect, insufficiently investigated even if numerous studies underline their impact on fertility, gametogenesis, embryonic development and pregnancies outcome. Obesity is considered as an independent risk factor for miscarriage, involved in oocyte and embryo quality, but also in endometrial receptivity. The male part involved in miscarriage was for a long time underestimated, neglecting the role of sperm in embryo development. If conventional sperm analysis remains essential, new investigations have to be considered such as sperm DNA or oxidant stress evaluation. It is particularly important to take into account nutritional factors as favoring miscarriage because they represent a flexible factor on which intervention is possible to improve pregnancy outcome, with toxics eviction and recommendations for diversified and well-balanced food. At last, effects of nutritional complements for miscarriage prevention remain controversial.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Abortion, Spontaneous / epidemiology*
  • Abortion, Spontaneous / etiology*
  • Alcohol Drinking / adverse effects
  • Caffeine / adverse effects
  • Celiac Disease / complications
  • Dietary Supplements
  • Embryo Implantation
  • Female
  • Humans
  • Male
  • Nutritional Status*
  • Obesity / complications
  • Pregnancy
  • Pregnancy Outcome
  • Risk Factors
  • Semen Analysis


  • Caffeine