Recent Advances in Copper-Catalyzed Dehydrogenative Functionalization via a Single Electron Transfer (SET) Process

Chem Soc Rev. 2012 May 7;41(9):3464-84. doi: 10.1039/c2cs15323h. Epub 2012 Feb 20.


Copper salts have been developed as versatile catalysts for oxidative coupling reactions in organic synthesis. During these processes, Cu-catalysts are often proposed to serve as a one-electron oxidant to promote the single-electron transfer process. Recently, the transition-metal catalyzed direct dehydrogenative transformation has attracted considerable attention. This tutorial review summarizes the recent advances in the copper-catalyzed dehydrogenative functionalization via a single electron transfer (SET) process achieving C-C, C-N, C-O, C-halogen atoms, C-P, and N-N bond formation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carbon / chemistry
  • Catalysis
  • Copper / chemistry*
  • Electron Transport
  • Halogens / chemistry
  • Nitrogen / chemistry
  • Oxygen / chemistry
  • Quantum Theory


  • Halogens
  • Carbon
  • Copper
  • Nitrogen
  • Oxygen