Diversity of metabotropic glutamate receptor-interacting proteins and pathophysiological functions

Adv Exp Med Biol. 2012;970:63-79. doi: 10.1007/978-3-7091-0932-8_3.

Abstract

In the mammalian brain, the large majority of excitatory synapses express pre- and postsynaptic glutamate receptors. These are ion channels and G protein-coupled membrane proteins that are organized into functional signaling complexes. Here, we will review the nature and pathophysiological functions of the scaffolding proteins associated to these receptors, focusing on the G protein-coupled subtypes.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / metabolism
  • Genetic Heterogeneity
  • Glutamic Acid / metabolism
  • Homer Scaffolding Proteins
  • Humans
  • Mammals
  • Mental Disorders / genetics
  • Mental Disorders / metabolism*
  • Mental Disorders / physiopathology
  • Mice
  • Neurodegenerative Diseases / genetics
  • Neurodegenerative Diseases / metabolism*
  • Neurodegenerative Diseases / physiopathology
  • Neurons / physiology
  • Post-Synaptic Density / genetics
  • Post-Synaptic Density / metabolism*
  • Protein Binding
  • Receptors, Metabotropic Glutamate / genetics
  • Receptors, Metabotropic Glutamate / metabolism*
  • Synaptic Transmission / physiology*

Substances

  • Carrier Proteins
  • Homer Scaffolding Proteins
  • Receptors, Metabotropic Glutamate
  • Glutamic Acid
  • GTP-Binding Proteins