PASADENA Hyperpolarized 13C Phospholactate

J Am Chem Soc. 2012 Mar 7;134(9):3957-60. doi: 10.1021/ja210639c. Epub 2012 Feb 28.

Abstract

We demonstrate that potassium 1-(13)C-phosphoenolpyruvate becomes hyperpolarized potassium 1-(13)C-phospholactate with (13)C T(1) = 36 s after molecular hydrogenation by PASADENA (Parahydrogen and Synthesis Allows Dramatically Enhanced Nuclear Alignment). This proof-of-principle study was conducted with a fully protonated molecular precursor. (13)C was polarized to a level of 1%, corresponding to nearly 4000-fold sensitivity enhancement at 3 T. The relevant homo- and heteronuclear spin-spin couplings are reported.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Carbon Isotopes
  • Lactates / chemical synthesis
  • Lactates / chemistry*
  • Magnetic Resonance Spectroscopy / standards
  • Molecular Structure
  • Potassium / chemistry
  • Reference Standards

Substances

  • Carbon Isotopes
  • Lactates
  • Potassium